buprenorphine transdermal and pentobarbital each maximize sedation. Stay away from or Use Alternate Drug. Limit use to sufferers for whom alternate therapy choices are insufficientpentobarbital will lessen the extent or impact of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Close to 25 to 50 perce